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In germ cells of humans and mice, precursors of PIWI-interacting RNAs piRNAs are transcribed from a few hundred sequence clusters, as well as individual transposons, intergenic regions, and genes in the genome. The 3' end is trimmed by an unknown exonuclease to generate the mature piRNA.

Transcriptional silencing by piRNAs is necessary to limit transposition of endogenous transposons such as L1 elements in the genome.

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Pillai, RSChuma, S. Girard, AHannon, GJ. Sato, KSiomi, MC. Bortvin, A. Chuma, SNakano, T. Toggle. About What is Reactome? Homo sapiens.

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Locations in the PathwayBrowser Expand all. Click the image above or here to open this pathway in the Pathway Browser. Cell Biol.

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Growth Differ. Go Biological Process.

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